Kisspeptins and RFRP-3 Act in Concert to Synchronize Rodent Reproduction with Seasons

  title={Kisspeptins and RFRP-3 Act in Concert to Synchronize Rodent Reproduction with Seasons},
  author={Val{\'e}rie Simonneaux and Caroline Ancel and Vincent Joseph Poirel and François Gauer},
  booktitle={Front. Neurosci.},
Seasonal mammals use the photoperiodic variation in the nocturnal production of the pineal hormone melatonin to synchronize their reproductive activity with seasons. In rodents, the (SD) short day profile of melatonin secretion has long been proven to inhibit reproductive activity. Lately, we demonstrated that melatonin regulates the expression of the hypothalamic peptides kisspeptins (Kp) and RFamide-related peptide-3 (RFRP-3), recently discovered as potent regulators of gonadotropin-releasing… CONTINUE READING
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