Kisspeptins (KiSS-1): essential players in suppressing tumor metastasis.

  title={Kisspeptins (KiSS-1): essential players in suppressing tumor metastasis.},
  author={Venugopal Vinod Prabhu and Kunnathur Murugesan Sakthivel and Chandrasekharan Guruvayoorappan},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  volume={14 11},
Kisspeptins (KPs) encoded by the KiSS-1 gene are C-terminally amidated peptide products, including KP- 10, KP-13, KP-14 and KP-54, which are endogenous agonists for the G-protein coupled receptor-54 (GPR54). Functional analyses have demonstrated fundamental roles of KiSS-1 in whole body homeostasis including sexual differentiation of brain, action on sex steroids and metabolic regulation of fertility essential for human puberty and maintenance of adult reproduction. In addition, intensive… CONTINUE READING


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