Kisspeptin signalling in the brain: steroid regulation in the rodent and ewe.

@article{Smith2008KisspeptinSI,
  title={Kisspeptin signalling in the brain: steroid regulation in the rodent and ewe.},
  author={Jeremy T. Smith},
  journal={Brain research reviews},
  year={2008},
  volume={57 2},
  pages={288-98}
}
The Kiss1 gene encodes a family of peptides called kisspeptins, which are the natural ligands for the receptor GPR54. In humans and mice, inactivating mutations of GPR54 results in hypogonadotropic hypogonadism, indicating that kisspeptins play a vital role in the regulation of GnRH secretion. In many species, centrally administered kisspeptins stimulate gonadotrophin secretion in a GnRH-dependant manner. Moreover, virtually all GnRH neurons coexpress GPR54. In the hypothalamus, the vast… CONTINUE READING
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