Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms.

@article{Luque2011KisspeptinRG,
  title={Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms.},
  author={Ra{\'u}l M Luque and Jos{\'e} C{\'o}rdoba-Chac{\'o}n and Manuel D Gahete and Victor M Navarro and Manuel Tena-Sempere and Rhonda D. Kineman and Justo P Casta{\~n}o},
  journal={Endocrinology},
  year={2011},
  volume={152 3},
  pages={957-66}
}
Kisspeptins (Kps) have emerged as key players in the control of reproductive-axis function, in which they operate as primary regulators of hypothalamic GnRH release. In addition, recent data indicate that Kps can also directly act on the pituitary to stimulate LH and GH release in primary pituitary cell culture prepared from rats, cows, and sheep. We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female… CONTINUE READING
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