Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo.

@article{Smith2008KisspeptinIP,
  title={Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo.},
  author={Jeremy T. Smith and A V Dhanunjaya Rao and Alda Pereira and Alain Caraty and Robert Peter Millar and I. J. Clarke},
  journal={Endocrinology},
  year={2008},
  volume={149 4},
  pages={1951-9}
}
There is strong evidence that kisspeptin acts to regulate GnRH secretion, but whether there is also a component of action on the gonadotropes is not clear. Using quantitative RT-PCR, we found that G protein-coupled receptor-54 mRNA is expressed in ovine pituitary cell fractions enriched for gonadotropes as well as in somatotropes and lactotropes. To test whether kisspeptin acts directly on the pituitary gonadotropes, we first examined LH release from primary ovine pituitary cell cultures… CONTINUE READING
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