Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha

@article{Franceschini2006KisspeptinIC,
  title={Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha},
  author={Isabelle Franceschini and Didier Lomet and Marilyn Cateau and Georges Delsol and Yves Tillet and Alain Caraty},
  journal={Neuroscience Letters},
  year={2006},
  volume={401},
  pages={225-230}
}
Localization of kisspeptin neurons in the hypothalamus of peripubertal female lambs; possible connection with gonadotrophin releasing hormone and neuropeptide Y neurons.
TLDR
The presence of very large numbers of kp-ir neurons in the peripubertal period could be attributed to their stimulating action on the GnRH neuronal system during this period, which could act directly in the median eminence (ME), where both peptides are released.
Evidence of kisspeptin receptor expression in GnRH neurons in the preoptic area and arcuate hypothalamic nuclei in cycling buffaloes
TLDR
Evidence of kisspeptin receptors in the GnRH neurons in buffalo POA and ARC areas is presented and it is suggested thatkisspeptin has a functional role in GnRH release in buffalo.
κ-Opioid Receptor Is Colocalized in GnRH and KNDy Cells in the Female Ovine and Rat Brain.
TLDR
The findings suggest that the inhibitory effects of dynorphin on pulsatile GnRH secretion may occur either indirectly by actions upon KOR within the KNDy population and/or directly via the activation of KOR on GnRH cells.
Immunocytochemical localization of kisspeptin neurons in the rat forebrain with special reference to sexual dimorphism and interaction with GnRH neurons.
TLDR
The results suggest thatkisspeptin-positive neurons, except for the ones in the ARC, are related not only to estrogen-positive feedback, but also sex dimorphism, and that kisspeptin regulates GnRH release in the ME rather than the POA.
Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge.
TLDR
Data suggest kisspeptin neurons located in the caudal extent of the ARC are involved in generating the positive feedback preovulatory GnRH/LH surge in the ewe, but there may also be a role for Kiss1-expressing cells in the POA.
Kisspeptin immunoreactive neurons in the equine hypothalamus Interactions with GnRH neuronal system
Morphological Evidence for Direct Interaction between Kisspeptin and Gonadotropin-Releasing Hormone Neurons at the Median Eminence of the Male Goat: An Immunoelectron Microscopic Study
TLDR
The present results suggest that the ARC kisspeptin neurons act on GnRH neurons at the ME to control (possibly the pulse mode of) GnRH secretion in males.
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.
TLDR
Data demonstrate that, in the ewe, a high percentage of ARC kisspeptin neurons also produce dynorphin and NKB, and it is proposed that a single subpopulation of ARC neurons contains all three neuropeptides.
Mapping of Kisspeptin Fibres in the Brain of the Pro‐Oestrous Rat
TLDR
Comparisons of the distribution of kisspeptin neurone fibres in the female rat brain by comparing precisely the immunoreactive pattern obtained with two antibodies suggest that these peptides play a role in different functions.
Kisspeptin neurons co‐express met‐enkephalin and galanin in the rostral periventricular region of the female mouse hypothalamus
TLDR
Observations indicate that, like the kisspeptin population of the arcuate nucleus,kisspeptin neurons in the RP3V also co‐express a range of neuropeptides, which should greatly increase the dynamic range with which kisspe leptin neurons can modulate the activity of their afferent neurons.
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References

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Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain.
TLDR
The colocalization of GnRH and kisspeptin within cells of the preoptic area and GnRH neurosecretory terminals of the median eminence suggests that the two peptides might be cosecreted into the hypophyseal portal blood to act on the pituitary gland.
Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion.
TLDR
Observations demonstrate that kisspeptin-GPR54 signaling in the brain serves as an important conduit for controlling GnRH secretion in the developing and adult animal.
LHRH-immunoreactive structures in the sheep brain
TLDR
It was found that 95% of the LHRH-immunoreactive cells are located in the preoptico-hypothalamic area, where cell bodies are localized mainly in the area surrounding the organum vasculosum of the lamina terminalis (OVLT).
Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats.
TLDR
Whether metastin, the product of metastasis suppressor gene KiSS-1, is a central neuropeptide regulating GnRH/LH surge and then estrous cyclicity in the female rat is examined.
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
TLDR
It is demonstrated that kisspeptin exerts a potent depolarizing effect on the excitability of almost all adult GnRH neurons and that the responsiveness of Gn RH neurons tokisspeptin increases over postnatal development.
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
TLDR
These results demonstrate that GnRH neurons are direct targets for regulation by kisspeptins and that KiSS-1 mRNA is regulated by gonadal hormones, suggesting that Ki SS-1 neurons play an important role in the feedback regulation of gonadotropin secretion.
Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide.
TLDR
The current data support the contention that the hypothalamic KiSS-1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
Oestrogen Receptors in the Preoptico‐Hypothalamic Continuum: Immunohistochemical Study of the Distribution and Cell Density During Induced Oestrous Cycle in Ovariectomized Ewe
TLDR
Experiments to identify the location of oestrogen receptors (ER) within the preoptico‐hypothalamic continuum of ovariectomized ewes submitted to a variety of different hormone replacement regimes which mimic the different stages of the oestrous cycle contribute towards the understanding of how steroids may act in the ovine to control sexual behaviour.
The Distribution of Cells Containing Estrogen Receptor-α (ERα) and ERβ Messenger Ribonucleic Acid in the Preoptic Area and Hypothalamus of the Sheep: Comparison of Males and Females
TLDR
Within sexes, the differences between the distributions of ERalpha and ERbeta mRNA-containing cells may reflect differential regulation of the actions of estrogen in the sheep hypothalamus and explain in part the sex differences in the neuroendocrine and behavioral responses to localized estrogen treatment in these nuclei.
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.
TLDR
GPR54 is defined as a major control point in the reproductive axis and kisspeptin is suggested to be a neurohormonal effector, demonstrating that a key action ofkisspeptin on the hypothalamo-pituitary-gonadal axis occurs directly at the level of GnRH release.
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