Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat

@inproceedings{Li2009KisspeptinSI,
  title={Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat},
  author={Xiao-Feng Li and James S. Kinsey-Jones and Yewsong Cheng and Alice M. I. Knox and Yuan Lin and Nikoletta A. Petrou and A K Roseweir and Stafford L. Lightman and Stuart R. Milligan and Robert Peter Millar and Kevin T O'Byrne},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Kisspeptin and its G protein-coupled receptor (GPR) 54 are essential for activation of the hypothalamo-pituitary-gonadal axis. In the rat, the kisspeptin neurons critical for gonadotropin secretion are located in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV) nuclei. As the ARC is known to be the site of the gonadotropin-releasing hormone (GnRH) pulse generator we explored whether kisspeptin-GPR54 signalling in the ARC regulates GnRH pulses. METHODOLOGY… CONTINUE READING