Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.

@article{Jayasena2014Kisspeptin54TE,
  title={Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.},
  author={Channa N Jayasena and Ali Abbara and Alexander N Comninos and Gurjinder Monica Kaur Nijher and Georgios Christopoulos and Shakunthala Narayanaswamy and Chioma N Izzi-Engbeaya and Mathini Sridharan and Alexina J Mason and Jane Warwick and Deborah A. Ashby and Mohammad A. Ghatei and Stephen R. Bloom and Anna Carby and Geoffrey H. Trew and Waljit S. Dhillo},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 8},
  pages={
          3667-77
        }
}
BACKGROUND Patients with mutations that inactivate kisspeptin signaling are infertile. Kisspeptin-54, the major circulating isoform of kisspeptin in humans, potently stimulates reproductive hormone secretion in humans. Animal studies suggest that kisspeptin is involved in generation of the luteinizing hormone surge, which is required for ovulation; therefore, we hypothesized that kisspeptin-54 could be used to trigger egg maturation in women undergoing in vitro fertilization therapy. METHODS… CONTINUE READING

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