Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males.

@article{Dhillo2005Kisspeptin54ST,
  title={Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males.},
  author={Waljit S. Dhillo and Owais B. Chaudhri and Michael Ty Patterson and Emily L. Thompson and Kevin Graeme Murphy and Michael K. Badman and Barbara M Mcgowan and Vian Amber and Sejal R. Patel and Mohammad A. Ghatei and Stephen R. Bloom},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 12},
  pages={
          6609-15
        }
}
CONTEXT Mutation of the G protein-coupled receptor 54 is associated with a failure of reproductive function. The endogenous neuropeptide agonist for G protein-coupled receptor 54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal axis in rodents and primates. OBJECTIVE The present study was designed to determine the effects of elevating circulating kisspeptin levels on LH, FSH, and testosterone in male volunteers. DESIGN This was a double-blind, placebo-controlled… CONTINUE READING
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