Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.

@article{Darnell2005KissingCR,
  title={Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.},
  author={Jennifer C. Darnell and Claire E. Fraser and Olga Mostovetsky and Giovanni Stefani and Thomas A Jones and Sean R. Eddy and Robert B Darnell},
  journal={Genes & development},
  year={2005},
  volume={19 8},
  pages={903-18}
}
Fragile-X mental retardation is caused by loss of function of a single gene encoding the Fragile-X mental retardation protein, FMRP, an RNA-binding protein that harbors two KH-type and one RGG-type RNA-binding domains. Previous studies identified intramolecular G-quartet RNAs as high-affinity targets for the RGG box, but the relationship of RNA binding to FMRP function and mental retardation remains unclear. One severely affected patient harbors a missense mutation (I304N) within the second KH… CONTINUE READING
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