Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice.

@article{Lapatto2007Kiss1ME,
  title={Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice.},
  author={Risto Lapatto and J. Carl Pallais and Dongsheng Zhang and Yee-Ming Chan and Amy L. Mahan and Felecia E. Cerrato and Wei Wei Le and Gloria E. Hoffman and Stephanie Beth Seminara},
  journal={Endocrinology},
  year={2007},
  volume={148 10},
  pages={
          4927-36
        }
}
The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene product kisspeptin) are key gatekeepers of sexual maturation. Gpr54 knockout mice demonstrate hypogonadotropic hypogonadism, but until recently, the phenotype of Kiss1 knockout mice was unknown. This report describes the reproductive phenotypes of mice carrying targeted deletions of Kiss1 or Gpr54 on the same genetic background. Both Kiss1 and Gpr54 knockout mice are viable but infertile and have abnormal… CONTINUE READING
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