Kiss‐and‐run and full‐collapse fusion as modes of exo‐endocytosis in neurosecretion

@article{Harata2006KissandrunAF,
  title={Kiss‐and‐run and full‐collapse fusion as modes of exo‐endocytosis in neurosecretion},
  author={N. Charles Harata and Alexander M. Aravanis and Richard W. Tsien},
  journal={Journal of Neurochemistry},
  year={2006},
  volume={97}
}
Neurotransmitters and hormones are released from neurosecretory cells by exocytosis (fusion) of synaptic vesicles, large dense‐core vesicles and other types of vesicles or granules. The exocytosis is terminated and followed by endocytosis (retrieval). More than fifty years of research have established full‐collapse fusion and clathrin‐mediated endocytosis as essential modes of exo‐endocytosis. Kiss‐and‐run and vesicle reuse represent alternative modes, but their prevalence and importance have… 
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TLDR
It is concluded that both mechanisms allow for high fidelity of vesicle recycling, and the presence in the plasma membrane of a depot of previously fused vesicles that are already interacting with the endocytotic machinery (the ‘readily retrievable’vesicles) allows full fusion to trigger quite fast endocyTosis, further blurring the efficiency differences between the two models.
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TLDR
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TLDR
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TLDR
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TLDR
Mechanisms of fusion pore stabilization in a narrow, release unproductive state are revealed, including SNAREs, which may facilitate and regulate the pre‐ and post‐fusional stages of exocytosis.
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TLDR
Studying the characteristics of astrocytic exocytosis will aid in the general understanding of this process and also events at the tripartite synapse, both in health and disease.
Fusion Pores, SNAREs, and Exocytosis
TLDR
To explain the stability of the initial narrow fusion pores, anisotropic membrane constituents with non-axisymmetrical shape were proposed to accumulate in the fusion pore membrane, including SNAREs, which may facilitate and regulate the pre- and post-fusional stages of exocytosis.
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