Kir6.2 is required for adaptation to stress.

  title={Kir6.2 is required for adaptation to stress.},
  author={Leonid V. Zingman and Denice M. Hodgson and P. Bast and Garvan C Kane and Carmen Perez-Terzic and Richard J. Gumina and Darko Pucar and Martin W. Bienengraeber and Petras P. Dzeja and Takashi Miki and Susumu Seino and Alexey Alekseev and Andre Terzic},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 20},
Reaction to stress requires feedback adaptation of cellular functions to secure a response without distress, but the molecular order of this process is only partially understood. Here, we report a previously unrecognized regulatory element in the general adaptation syndrome. Kir6.2, the ion-conducting subunit of the metabolically responsive ATP-sensitive potassium (K(ATP)) channel, was mandatory for optimal adaptation capacity under stress. Genetic deletion of Kir6.2 disrupted K(ATP) channel… CONTINUE READING
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Cardiac adenine nucleotide content at baseline and after stress Baseline, n 4 6 Exercise, n 6 8 Isoproterenol, n 5 5 ATP ADP AMP Total ATP ADP ATP ADP AMP Total ATP ADP ATP ADP AMP Total ATP ADP WT

  • C. Nasuhoglu, S. Feng, +5 authors D. W. Hilgemann
  • Am. J. Physiol
  • 2002

Stress Without Distress (New American Library, New York)

  • H. Selye
  • 1974

The Wisdom of the Body (WW Norton, New York)

  • W. B. Cannon
  • 1939

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