Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination.

@article{Neusch2001Kir41PC,
  title={Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination.},
  author={Clemens Neusch and Nora Rozengurt and Russell E. Jacobs and Henry A. Lester and Paulo Kofuji},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 15},
  pages={5429-38}
}
To understand the cellular and in vivo functions of specific K(+) channels in glia, we have studied mice with a null mutation in the weakly inwardly rectifying K(+) channel subunit Kir4.1. Kir4.1-/- mice display marked motor impairment, and the cellular basis is hypomyelination in the spinal cord, accompanied by severe spongiform vacuolation, axonal swellings, and degeneration. Immunostaining in the spinal cord of wild-type mice up to postnatal day 18 reveals that Kir4.1 is expressed in myelin… CONTINUE READING
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