Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1

@article{Vucic2014Kir11A,
  title={Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1},
  author={Esad Vucic and Tariq I. Alfadda and Gordon G. MacGregor and Ke Dong and Tong Hua Wang and John P. Geibel},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2014},
  volume={467},
  pages={1457-1468}
}
Potassium channels comprise the apical leak pathway supplying extracellular K+ for exchange with protons by the gastric H+, K+-ATPase and provide potential therapeutic targets for inhibiting gastric acid secretion. The Kir1.1 (ROMK) potassium channel mediates the high capacity K+ recycling necessary for NaCl reabsorption in the thick ascending limb of the kidney, and this channel exhibits functional and regulatory characteristic well suited for K+ recycling by gastric parietal cells. We report… CONTINUE READING
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