Kinins contribute to the improvement of insulin sensitivity during treatment with angiotensin converting enzyme inhibitor.

@article{Tomiyama1994KininsCT,
  title={Kinins contribute to the improvement of insulin sensitivity during treatment with angiotensin converting enzyme inhibitor.},
  author={Hirofumi Tomiyama and Toshio Kushiro and Hiromi Abeta and Toshikazu Ishii and A. S. C. Takahashi and Luzia N.S. Furukawa and Tomoko Asagami and Toru Hino and Fumitoshi Saito and Yuko Otsuka},
  journal={Hypertension},
  year={1994},
  volume={23 4},
  pages={
          450-5
        }
}
Although angiotensin converting enzyme inhibitors and alpha 1-blockers have been reported to improve insulin sensitivity, their mechanisms of action have not been elucidated. To investigate the role of kinins in insulin sensitivity, we treated 4-week-old spontaneously hypertensive rats with either an angiotensin converting enzyme inhibitor (enalapril), an alpha 1-blocker (doxazosin), or an angiotensin II antagonist (losartan) for 3 weeks. A control group received no drugs. In addition, 18 rats… CONTINUE READING

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