Kinins and peritoneal exudates induced by carrageenin and zymosan in rats

@article{Damas1990KininsAP,
  title={Kinins and peritoneal exudates induced by carrageenin and zymosan in rats},
  author={Jacques Damas and Victor Bourdon and G. Remacle-Volon and Albert Adam},
  journal={British Journal of Pharmacology},
  year={1990},
  volume={101}
}
1 Kinins were measured by a radioimmunoassay in the inflammatory exudates induced by carrageenin or zymosan in the peritoneal cavity of normal Wistar rats and of kininogen‐deficient Brown Norway rats. 2 After administration of carrageenin to normal rats, levels of immunoreactive kinins showed a single peak during the first two hours and then decreased. The presence of kinins preceded and accompanied the exudation of 125I‐labelled albumin. Kinins were identified as bradykinin by chromatography… Expand
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α-Phellandrene, a cyclic monoterpene, attenuates inflammatory response through neutrophil migration inhibition and mast cell degranulation.
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The role of T‐kininogen in this kind of exudate was mainly the inhibition of thiol proteinases and not the release of T•kinin, and in Wistar rats, bradykinin acts as a pro‐inflammatory factor during the first hours and may play a role during the healing process. Expand
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The results indicate that kaolin-induced pleurisy is a kinin-related inflammation and could be used as a model for studying the in vivo interaction of the kallikrein-kinin system and PGs at inflammatory sites. Expand
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The kinin system is involved during the first hours of the development of this acute inflammatory reaction, and the anti-inflammatory effect of SBTI does not depend on the inhibition of kinin formation. Expand
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Bradykinin played a definite role in sustaining a high level of vascular permeability response in the late stage in conjunction with prostaglandins and was suppressed below the sensitivity limit of the assay. Expand
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The zymosan‐induced exudate fluid contained a microvascular permeability‐increasing factor or factors which, unlike histamine and bradykinin, had a long duration of action when tested in rabbit skin and was dependent on circulating PMNLs. Expand
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TLDR
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TLDR
It is shown that carrageenan activates Hageman factor (factor XII) in human plasma, and thus promotes blood coagulation, induces vascular permeability, and liberates kinin, at higher concentrations it also acts as an anticoagulant. Expand
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