Kinin metabolism in human nasal secretions during experimentally induced allergic rhinitis.

@article{Proud1987KininMI,
  title={Kinin metabolism in human nasal secretions during experimentally induced allergic rhinitis.},
  author={David Proud and Claus R Baumgarten and Robert M. Naclerio and Phillip E Ward},
  journal={Journal of immunology},
  year={1987},
  volume={138 2},
  pages={428-34}
}
We have previously shown that both bradykinin and lysylbradykinin are generated in nasal secretions upon nasal challenge of allergic individuals with appropriate allergen and have suggested that these potent pro-inflammatory peptides may contribute to the pathogenesis of the allergic response. In this study we used a variety of synthetic substrates together with both thin layer and high performance liquid chromatography systems to examine the metabolism of these peptides in nasal secretions… CONTINUE READING

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