King George III and porphyria: an elemental hypothesis and investigation

  title={King George III and porphyria: an elemental hypothesis and investigation},
  author={T. Cox and Nicola Jack and S. Lofthouse and J. Watling and M. Warren},
  journal={The Lancet},
  • T. Cox, Nicola Jack, +2 authors M. Warren
  • Published 2005
  • Medicine
  • The Lancet
  • In 1969 it was proposed that the episodic madness suffered by King George III (1738-1820) resulted from an acute hereditary porphyria, variegate porphyria, caused by deficiency of protoporphyrinogen oxidase. The diagnosis was based on the historical archive and a contentious claim that living members of the House of Hanover were affected with the condition. A re-examination of the medical evidence and the appearance of new historical material have suggested that porphyria did indeed exist in… CONTINUE READING
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