Kinetoplastid-specific histone variant functions are conserved in Leishmania major.

  title={Kinetoplastid-specific histone variant functions are conserved in Leishmania major.},
  author={Britta A Anderson and Iris L. K. Wong and Loren Baugh and Gowthaman Ramasamy and Peter J. Myler and Stephen M Beverley},
  journal={Molecular and biochemical parasitology},
  volume={191 2},
Regions of transcription initiation and termination in kinetoplastid protists lack known eukaryotic promoter and terminator elements, although epigenetic marks such as histone variants and the modified DNA base J have been localized to these regions in Trypanosoma brucei, Trypanosoma cruzi, and/or Leishmania major. Phenotypes of base J mutants vary significantly across trypanosomatids, implying divergence in the epigenetic networks governing transcription during evolution. Here, we demonstrate… CONTINUE READING


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