Kinetochore-microtubule interactions: steps towards bi-orientation.

  title={Kinetochore-microtubule interactions: steps towards bi-orientation.},
  author={Tomoyuki U Tanaka},
  journal={The EMBO journal},
  volume={29 24},
Eukaryotic cells segregate their chromosomes accurately to opposite poles during mitosis, which is necessary for maintenance of their genetic integrity. This process mainly relies on the forces generated by kinetochore-microtubule (KT-MT) attachment. During prometaphase, the KT initially interacts with a single MT extending from a spindle pole and then moves towards a spindle pole. Subsequently, MTs from the other spindle pole also interact with the KT. Eventually, one sister KT becomes… CONTINUE READING

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