Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

Abstract

During vertebrate mitosis, the centromere-associated kinesin CENP-E (centromere protein E) transports misaligned chromosomes to the plus ends of spindle microtubules. Subsequently, the kinetochores that form at the centromeres establish stable associations with microtubule ends, which assemble and disassemble dynamically. Here we provide evidence that after… (More)
DOI: 10.1038/ncb2831

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