Kinetochore geometry defined by cohesion within the centromere

@article{Sakuno2009KinetochoreGD,
  title={Kinetochore geometry defined by cohesion within the centromere},
  author={Takeshi Sakuno and Kenji Tada and Yoshinori Watanabe},
  journal={Nature},
  year={2009},
  volume={458},
  pages={852-858}
}
During cell division microtubules capture chromosomes by binding to the kinetochore assembled in the centromeric region of chromosomes. In mitosis sister chromatids are captured by microtubules emanating from both spindle poles, a process called bipolar attachment, whereas in meiosis I sisters are attached to microtubules originating from one spindle pole, called monopolar attachment. For determining chromosome orientation, kinetochore geometry or structure might be an important target of… CONTINUE READING
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