Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing beta-lactamase.

@article{Alba2005KineticsSO,
  title={Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing beta-lactamase.},
  author={Jimena Alba and Yoshikazu Ishii and Kenneth S Thomson and Ellen Smith Moland and Keizo Yamaguchi},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 11},
  pages={
          4760-2
        }
}
The kinetic activity of KPC-3, a plasmid-encoded class A carbapenemase, was studied. It hydrolyzed penicillins, cephalosporins, carbapenems, and even sulbactam. The best substrate was cephalothin (k(cat/K)m = 3.48 microM(-1) s(-1)). The efficiency of the enzyme was similar for imipenem and meropenem (k(cat)/K(m), 1.4 and 1.94 microM(-1) s(-1), respectively). 

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