Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infection.

@article{Marten2003KineticsOV,
  title={Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infection.},
  author={Norman W. Marten and Stephen A. Stohlman and Jiehao Zhou and Cornelia C. Bergmann},
  journal={Journal of virology},
  year={2003},
  volume={77 4},
  pages={2775-8}
}
CD8+ T cells control acute infection of the central nervous system (CNS) by neurotropic mouse hepatitis virus but do not suffice to achieve sterile immunity. To determine the lag between T-cell priming and optimal activity within the CNS, the accumulation of virus-specific CD8+ T cells in the CNS relative to that in peripheral lymphoid organs was assessed by using gamma interferon-specific ELISPOT assays and class I tetramer staining. Virus-specific CD8+ T cells were first detected in the… CONTINUE READING