Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.

@article{Wenzlau2010KineticsOT,
  title={Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.},
  author={Janet M. Wenzlau and Mary Walter and Thomas J. Gardner and Lisa M. Frisch and Liping Yu and George S. Eisenbarth and Anette-Gabriele Ziegler and Howard W Davidson and John C. Hutton},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 10},
  pages={4712-9}
}
CONTEXT Zinc transporter 8 (ZnT8) is a newly discovered islet autoantigen in human type 1A diabetes (T1D). OBJECTIVE The objective was to document changes in ZnT8 autoantibody (ZnT8A) titer and prevalence after onset of disease in relationship to 65 kDa glutamate decarboxylase antibody (GADA) and islet cell antigen antibody (IA2A). DESIGN/PATIENTS Autoantibody radioimmunoprecipitation assays were performed on sera from three groups: 21 individuals monitored every 3 months from diagnosis for… CONTINUE READING
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