Kinetics of the inhibition of plasmin in acidified human plasma.

  title={Kinetics of the inhibition of plasmin in acidified human plasma.},
  author={Henri Roger Lijnen and Michael Maes and Mona Castel and M S Samama and D{\'e}sir{\'e} Collen},
  journal={Thrombosis and haemostasis},
  volume={48 3},
Acid-treated human plasma is a competitive inhibitor of the hydrolysis of D-Val-Leu-Lys-Nan (S-2251) by plasmin. The rate of hydrolysis is decreased to 50% by 750 fold diluted acidified normal plasma and by 60 fold diluted acidified alpha 2-antiplasmin depleted plasma (alpha 2-antiplasmin concentration less than 2%). These findings suggest that alpha 2-antiplasmin is a contributary but not the main competitive inhibitor of acidified plasma. This interpretation is supported by the finding that… CONTINUE READING

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