Kinetics of the association/dissociation cycle of an ATP-binding cassette nucleotide-binding domain.

Abstract

Most ATP binding cassette (ABC) proteins are pumps that transport substrates across biological membranes using the energy of ATP hydrolysis. Functional ABC proteins have two nucleotide-binding domains (NBDs) that bind and hydrolyze ATP, but the molecular mechanism of nucleotide hydrolysis is unresolved. This is due in part to the limited kinetic information… (More)
DOI: 10.1074/jbc.M111.318378

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