Kinetics of superoxide scavenging by glutathione: an evaluation of its role in the removal of mitochondrial superoxide.

@article{Jones2003KineticsOS,
  title={Kinetics of superoxide scavenging by glutathione: an evaluation of its role in the removal of mitochondrial superoxide.},
  author={Clare M. Jones and Andrew J Lawrence and Peter Wardman and Mark J. Burkitt},
  journal={Biochemical Society transactions},
  year={2003},
  volume={31 Pt 6},
  pages={1337-9}
}
Superoxide radicals are produced in trace amounts by the mitochondrial respiratory chain. Most are removed rapidly by superoxide dismutase in the matrix. Superoxide is also known to react with glutathione. Reported values of the rate constant for this reaction range from 10(2) to in excess of 10(5) M(-1).s(-1). The magnitude of this rate constant has important physiological implications because, if it is at the upper end of the reported range, a significant proportion of mitochondrial… CONTINUE READING