Kinetics of suicide substrates. Practical procedures for determining parameters.

@article{Waley1985KineticsOS,
  title={Kinetics of suicide substrates. Practical procedures for determining parameters.},
  author={S. G. Waley},
  journal={The Biochemical journal},
  year={1985},
  volume={227 3},
  pages={843-9}
}
Many clinically important or mechanistically interesting inhibitors react with enzymes by a branched pathway in which inactivation of the enzyme and formation of product are competing reactions. The steady-state kinetics for this pathway [Waley (1980) Biochem. J. 185, 771-773] gave equations for progress curves that were cumbersome. A convenient linear plot… CONTINUE READING