Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism.

@article{Ferrone1985KineticsOS,
  title={Kinetics of sickle hemoglobin polymerization. II. A double nucleation mechanism.},
  author={Frank A. Ferrone and James Hofrichter and William Allen Eaton},
  journal={Journal of molecular biology},
  year={1985},
  volume={183 4},
  pages={611-31}
}
A double nucleation mechanism for the polymerization of sickle hemoglobin is described. The mechanism accounts for all of the major kinetic observations: the appearance of a delay, the high concentration dependence of the delay time, and the stochastic behavior of slowly polymerizing samples in small volumes. The mechanism postulates that there are two pathways for polymer formation: polymerization is initiated by homogeneous nucleation in the solution phase, followed by nucleation of… CONTINUE READING
98 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 98 extracted citations

Similar Papers

Loading similar papers…