Kinetics of serotonin uptake in isolated rabbit lungs.

  title={Kinetics of serotonin uptake in isolated rabbit lungs.},
  author={F. A. M. Peeters and Thomas A. Bronikowski and Christopher A. Dawson and John H. Linehan and Hidde Bult and Arnold G. Herman},
  journal={Journal of applied physiology},
  volume={66 5},
The single-pass, bolus-injection method was used to study the effect of serotonin (5-HT) concentration on the extraction of 5-HT by isolated perfused rabbit lungs. The extraction pattern suggested that an uptake model, which includes multiple parallel uptake processes, provided a better representation of the data than the simple Michaelis-Menten equation, which has commonly been used to fit the saturable uptake data in previous studies. In particular, the rabbit lung data could be fit with two… CONTINUE READING

From This Paper

Topics from this paper.