Kinetics of self-assembling microtubules: an "inverse problem" in biochemistry.

@article{Flyvbjerg1996KineticsOS,
  title={Kinetics of self-assembling microtubules: an "inverse problem" in biochemistry.},
  author={Henrik Flyvbjerg and E Jobs and Stanislas Leibler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 12},
  pages={
          5975-9
        }
}
Experimental time series for a nonequilibrium reaction may in some cases contain sufficient data to determine a unique kinetic model for the reaction by a systematic mathematical analysis. As an example, a kinetic model for the self-assembly of microtubules is derived here from turbidity time series for solutions in which microtubules assemble. The model may be seen as a generalization of Oosawa's classical nucleation-polymerization model. It reproduces the experimental data with a four-stage… CONTINUE READING
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