Kinetics of regional blood-brain barrier glucose transport and cerebral blood flow determined with the carotid injection technique in conscious rats.

@article{Braun1985KineticsOR,
  title={Kinetics of regional blood-brain barrier glucose transport and cerebral blood flow determined with the carotid injection technique in conscious rats.},
  author={Leon D Braun and Leonard P. Miller and William M Pardridge and William H. Oldendorf},
  journal={Journal of neurochemistry},
  year={1985},
  volume={44 3},
  pages={911-5}
}
Anesthetics, particularly barbiturates, have depressive effects on cerebral blood flow and metabolism and likely have similar effects on blood-brain barrier (BBB) transport. In previous studies utilizing the carotid injection technique, it was necessary to anesthetize the animals prior to performing the experiment. The carotid injection technique was modified by catheter implantation in the external carotid artery at the bifurcation of the common carotid artery. The technique was used to… CONTINUE READING
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