Kinetics of protein-nucleic acid interactions: use of salt effects to probe mechanisms of interaction.

@article{Lohman1986KineticsOP,
  title={Kinetics of protein-nucleic acid interactions: use of salt effects to probe mechanisms of interaction.},
  author={Timothy M. Lohman},
  journal={CRC critical reviews in biochemistry},
  year={1986},
  volume={19 3},
  pages={
          191-245
        }
}
The kinetics of protein-nucleic acid interactions are discussed with particular emphasis on the effects of salt concentration and valence on the observed rate constants. A general review is given of the use of experimentally determined salt dependences of observed kinetic parameters as a tool to probe the mechanism of interaction. Quantitative analysis of these salt dependences, through the application of polyelectrolyte theory, can be used to distinguish reactions which occur in a single step… CONTINUE READING

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