Kinetics of propylene glycol elimination and metabolism in rat.

@article{Morshed1988KineticsOP,
  title={Kinetics of propylene glycol elimination and metabolism in rat.},
  author={K M Morshed and Joginder Nagpaul and Siddhartha Majumdar and M. K. P. Amma},
  journal={Biochemical medicine and metabolic biology},
  year={1988},
  volume={39 1},
  pages={90-7}
}
The kinetics of 1,2-propanediol (PD) metabolism in vivo have been determined by employing the Michaelis-Menten rate equation; it was found that maximum metabolizing capacity was 8.33 mmole PD/kg/hr in the rat, which is equivalent to 1.06 kg/day for an average 70-kg human. The rate equation could be suitably used for optimizing the dosage schedule of a drug from the linear elimination pattern; in the present case this gave a Km value of 17.86 mmole/kg on the basis of the elimination rate of PD… CONTINUE READING