Kinetics of plasma total homocysteine in patients receiving high-dose methotrexate therapy.

@article{Guttormsen1998KineticsOP,
  title={Kinetics of plasma total homocysteine in patients receiving high-dose methotrexate therapy.},
  author={Anne Berit Guttormsen and Per Magne Ueland and Per Eystein L{\o}nning and Olav Mella and Helge Refsum},
  journal={Clinical chemistry},
  year={1998},
  volume={44 9},
  pages={
          1987-9
        }
}
  • Anne Berit Guttormsen, Per Magne Ueland, +2 authors Helge Refsum
  • Published in Clinical chemistry 1998
  • Chemistry, Medicine
  • Homocysteine (Hcy) is a sulfur amino acid formed from methionine during transmethylation. Once formed, it is either remethylated to methionine or irreversibly catabolized to cystathionine. The remethylation is catalyzed by methionine synthase (EC 2.1.1.13), which requires cobalamin as cofactor and 5-methyltetrahydrofolate as substrate (1) . This explains why the fasting total homocysteine (tHcy) concentration is related to overall folate or cobalamin status and that increased tHcy has been used… CONTINUE READING

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