Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man.

@article{Wagner1968KineticsOP,
  title={Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man.},
  author={John G. Wagner},
  journal={Journal of theoretical biology},
  year={1968},
  volume={20 2},
  pages={
          173-201
        }
}
  • J. Wagner
  • Published 1 August 1968
  • Biology
  • Journal of theoretical biology
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308 Citations
Highly Influential Citations
6
Background Citations
36
Methods Citations
44

308 Citations

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  • 1977
The time courses of blood levels, tissue levels and amounts excreted of an administered drug and its formed metabolites can be monitored simultaneously with observed pharmacological, toxicological or…
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It is demonstrated that through the suitable use of intravenous dose-effect curves, the postulation of hypothetical models for pharmacon-receptor site interaction is obviated and the relationship between the quantity of drug in body compartments (biophase) and the observed intensity of drug response is graphically provided.
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References

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  • Medicine, Biology
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TLDR
Pharmacokinetic analysis of pharmacologic activity data can lead to better understanding of the relationship between dose and the multiple pharmacologic effects elicited by a drug, and it can facilitate the assessment of factors which account for individual variations in the response to drugs.
Blood Levels of Drug at the Equilibrium State after Multiple Dosing
THERE is ample evidence1–20 that when a fixed dose of drug is administered in a fixed multiple-dose regimen, the blood levels of drug eventually reach a steady state in which the blood level time…
Some formal approaches to the analysis of kinetic data in terms of linear compartmental systems.
RELATIONSHIP BETWEEN RATE OF ELIMINATION OF TUBOCURARINE AND RATE OF DECLINE OF ITS PHARMACOLOGICAL ACTIVITY.
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  • Medicine
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SUMMARY It is shown on theoretical grounds that, assuming tubocurarine elimination is an exponential process and the intensity of its pharmacological activity is proportional to the logarithm of the…
The Determination of Enzyme Dissociation Constants
On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, (ES), a t all values of the concentration of the…
Apparent Potentiating Effect of a Second Dose of Drug
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The purpose of this communication is to suggest a pharmacokinetic basis for this apparent potentiation of a drug after its apparent disappearance.
The routine fitting of kinetic data to models: a mathematical formalism for digital computers.
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Introduction to Chemical Pharmacology
RELATIONSHIP BETWEEN ELIMINATION RATE OF DRUGS AND RATE OF DECLINE OF THEIR PHARMACOLOGIC EFFECTS.
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  • Medicine
    Journal of pharmaceutical sciences
  • 1964
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