Kinetics of mezlocillin and carbenicillin.

  title={Kinetics of mezlocillin and carbenicillin.},
  author={S J Pancoast and Harold C. Neu},
  journal={Clinical pharmacology and therapeutics},
  volume={24 1},
The kinetics of mezlocillin, a semisynthetic acylureido penicillin, more active than carbenicillin against many gram-negative bacteria, were compared with those of carbenicillin. Following an intravenous infusion of 4 gm in 5 min to 8 normal men there was an average serum level of 294 microgram/ml for mezlocillin and 365 microgram/ml for carbenicillin. The t1/2 for mezlocillin was 47 min and that for carbencillin was 70 min. The apparent volume of distribution was 13.4 L for mezlocillin and 14… CONTINUE READING