Kinetics of lactate metabolism during acellular normothermic ex vivo lung perfusion.

@article{Koike2011KineticsOL,
  title={Kinetics of lactate metabolism during acellular normothermic ex vivo lung perfusion.},
  author={Terumoto Koike and Jonathan Chi-Wai Yeung and Marcelo Cypel and Matthew Rubacha and Yasushi Matsuda and Masaaki Sato and Thomas K Waddell and Mingyao Liu and Shaf H Keshavjee},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2011},
  volume={30 12},
  pages={
          1312-9
        }
}
BACKGROUND Plasma lactate has been used as a marker of poor prognosis in clinical conditions. However, the relationship between lactate production and lung function during acellular normothermic ex vivo lung perfusion (EVLP) is unclear. We investigated the kinetics of lactate metabolism during EVLP and the correlation of this marker with outcomes after transplant. METHODS Human donor lungs in our clinical EVLP trial (CLs; n = 28) and rejected donor lungs for experimental use (Els; n = 8) were… CONTINUE READING
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