Kinetics of l-5-hydroxytryptophan in healthy subjects

@article{Westenberg1982KineticsOL,
  title={Kinetics of l-5-hydroxytryptophan in healthy subjects},
  author={Herman G. M. Westenberg and Ton W. Gerritsen and Bert A. Meijer and Herman M. van Praag},
  journal={Psychiatry Research},
  year={1982},
  volume={7},
  pages={373-385}
}
The kinetics of l-5-hydroxytryptophan (5-HTP) were studied in five volunteers after intravenous and oral administration of 5-HTP following pretreatment with carbidopa. In addition, the effect of pretreatment with carbidopa on metabolism and disposition of 5-HTP was studied in eight subjects. The kinetics of 5-HTP following a 20-minute linear infusion are adequately described by a biexponential function. The biological half-life of 5-HTP ranged from 2.2 to 7.4 hours, and the plasma clearance… Expand
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METABOLISM OF CARBIDOPA [L-(-)-α-HYDRAZINO-3,4-DIHYDROXY-α-METHYLHYDROCINNAMIC ACID MONOHYDRATE], AN AROMATIC AMINO ACID DECARBOXYLASE INHIBITOR, IN THE RAT, DOG, RHESUS MONKEY, AND MAN
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