Kinetics of irreversible inhibition of choline transport in synaptosomes by ethylcholine mustard aziridinium

Abstract

Ethylcholine mustard aziridinium (ECMA) inhibits choline transport in synaptosomes at a half-maximal concentration of about 20 μm. The rate of inhibition falls off rapidly after 10 min and the concentration dependency reaches a plateau at about 100 μm. The inhibition is not removed by washing the synaptosomes, and choline and hemicholinium-3 protect the… (More)
DOI: 10.1007/BF01871635

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