Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport.

@article{Dhungana2005KineticsOI,
  title={Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport.},
  author={Suraj Dhungana and Damon S. Anderson and Timothy A. Mietzner and Alvin L. Crumbliss},
  journal={Biochemistry},
  year={2005},
  volume={44 28},
  pages={9606-18}
}
The ferric binding protein (FbpA) transports iron across the periplasmic space of certain Gram-negative bacteria and is an important component involved in iron acquisition by pathogenic Neisseria spp. (Neisseria gonorrheae and Neisseria meningitidis). Previous work has demonstrated that the synergistic anion, required for tight Fe(3+) sequestration by FbpA, also plays a key role in inserting Fe(3+) into the FbpA binding site. Here, we investigate the iron release process from various forms of… CONTINUE READING

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