Kinetics of intravenous melphalan.

  title={Kinetics of intravenous melphalan.},
  author={David S. Alberts and Sai Y. Chang and H. S. Chen and Thomas E. Moon and Thomas L. Evans and R L Furner and Kenneth J. Himmelstein and Joseph F. Gross},
  journal={Clinical pharmacology and therapeutics},
  volume={26 1},
We have studied the disposition and elimination of melphalan after intravenous administration in 9 patients with cancer. High-pressure liquid chromatography and 14C-melphalan were used to assay drug concentration in plasma and urine. Composite plasma t1/2alpha was 7.7 +/- 3.3 and t1/2beta was 108 +/- 20.8 min for 8 of the patients. The mean 24-hr urinary excretion of melphalan was 13.0 +/- 5.4% of the administered dose. In 2 patients, 80% to 100% of the measured 14C counts in plasma and urine… CONTINUE READING