Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

@article{Sluzky1991KineticsOI,
  title={Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.},
  author={Victoria Sluzky and Janet A. Tamada and Alexander M. Klibanov and Robert Langer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 21},
  pages={
          9377-81
        }
}
The stability of protein-based pharmaceuticals (e.g., insulin) is important for their production, storage, and delivery. To gain an understanding of insulin's aggregation mechanism in aqueous solutions, the effects of agitation rate, interfacial interactions, and insulin concentration on the overall aggregation rate were examined. Ultraviolet absorption spectroscopy, high-performance liquid chromatography, and quasielastic light scattering analyses were used to monitor the aggregation reaction… CONTINUE READING

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