Kinetics of immune parameters in a patient with sepsis caused by Streptococcus pyogenes treated with activated protein C.


We report a case of streptococcal sepsis treated with recombinant human activated protein C (rhAPC). High plasma IL-6 and cortisol levels at baseline significantly decreased 24 h following the infusion of rhAPC. This decrease was accompanied by a rise of circulating lymphocyte subsets. Our observation may be due to immunomodulatory properties of rhAPC. 


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