Kinetics of hydrolysis of barbituric acid derivatives.

@article{Garrett1971KineticsOH,
  title={Kinetics of hydrolysis of barbituric acid derivatives.},
  author={E. R. Garrett and J. Bojarşki and G. Yakatan},
  journal={Journal of pharmaceutical sciences},
  year={1971},
  volume={60 8},
  pages={
          1145-54
        }
}
The neutral and alkaline hydrolyses of barbituric acid and some of its substituted derivatives were followed spectrophotometrically. The rate‐pH profiles for all of the 5,5‐disubstituted barbiturates were similar. A different profile was observed for barbituric acid because of its comparatively low pKa1'. The rate‐pH profile of metharbital showed no curvature at high pH values, since the 1‐methyl substituent prevents the second possible proton dissociation. All profiles could be explained by… Expand
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