Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.

@article{Good2006KineticsOH,
  title={Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.},
  author={Kim L. Good and Vanessa L. Bryant and Stuart G Tangye},
  journal={Journal of immunology},
  year={2006},
  volume={177 8},
  pages={5236-47}
}
Although recent studies indicated that IL-21 is an important regulator of human B cell activation, detailed comparison of the effects of IL-21 on distinct B cell subsets have not been performed. Our studies revealed that IL-21R is expressed by naive and germinal center B cells, but not memory or plasma cells. IL-21R was increased on naive and memory B cells following in vitro activation. Investigation into the kinetics and magnitude of responses of human B cells to IL-21 revealed that IL-21… CONTINUE READING

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