Kinetics of hepatic uptake of unconjugated bilirubin.

@article{Paumgartner1976KineticsOH,
  title={Kinetics of hepatic uptake of unconjugated bilirubin.},
  author={Gustav Paumgartner and Juerg Reichen},
  journal={Clinical science and molecular medicine},
  year={1976},
  volume={51 2},
  pages={169-76}
}
1. The uptake of bilirubin was studied in the perfused rat liver by a multiple-indicator dilution technique employing the three-compartment model of Goresky. 2. The kinetics of hepatic bilirubin uptake could be described by the Michaelis-Menten equation. 3. The maximal uptake velocity (V max.) and the apparent half-saturation constant (Km) were 4-4 +/- 0-5 nmol s-1 g-1 of liver and 58 +/- 16 nmol/g of liver respectively, indicating that the hepatic uptake system for bilirubin under normal… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Kinetic analysis of the dose-dependent hepatic handling of 1-anilino-8-naphthalene sulfonate in rats

Journal of Pharmacokinetics and Biopharmaceutics • 1990
View 4 Excerpts
Highly Influenced

Organic anion uptake by hepatocytes.

Comprehensive Physiology • 2014
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Protein binding and conjugation of bilirubin in the liver

cell. In: Jaundice, • 1975
View 4 Excerpts
Highly Influenced

Binding proteins and hepatic uptake and transport of bilirubin

J. A. T. P. MEUWISSEN
Digestion • 1975

Diagnostische Bedeutung der SerumgallensBuren

H. P. SCHWARZ, G. PAUMGARTNER, R. PREISIG
Schweizerische Medirinische Wochenschrift, • 1975

Morphine metabolism in vivo and in vitro by homozygous Gunn rats.

The Journal of pharmacology and experimental therapeutics • 1974

Binding of bilirubin to erythrocytes.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine • 1973

Similar Papers

Loading similar papers…