Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis.

@article{Zhu2001KineticsOH,
  title={Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis.},
  author={Yuao Zhu and Toshiki Yamamoto and John Cullen and Jeffry R Saputelli and Carol E Aldrich and Darren S. Miller and Samuel Litwin and Phillip A. Furman and Allison R. Jilbert and William S. Mason},
  journal={Journal of virology},
  year={2001},
  volume={75 1},
  pages={311-22}
}
Hepadnaviruses replicate by reverse transcription, which takes place in the cytoplasm of the infected hepatocyte. Viral RNAs, including the pregenome, are transcribed from a covalently closed circular (ccc) viral DNA that is found in the nucleus. Inhibitors of the viral reverse transcriptase can block new DNA synthesis but have no direct effect on the up to 50 or more copies of cccDNA that maintain the infected state. Thus, during antiviral therapy, the rates of loss of cccDNA, infected… CONTINUE READING